Jürgen Altmann of the Dortmund University of Technology, an expert on sonic weapons, has said that there is no reliable evidence for nausea and vomiting caused by infrasound.
High volume levels at concerts from subwoofer arrays have been cited as causing lung collapse in individuals who are very close to the subwoofers, especially for smokers who are particularly tall and thin.
In September 2009, London student Tom Reid died of sudden arrhythmic death syndrome (SADS) after complaining that "loud bass notes" were "getting to his heart". The inquest recorded a verdict of natural causes, although some experts commented that the bass could have acted as a trigger.
Air is a very inefficient medium for transferring low frequency vibration from a transducer to the human body. Mechanical connection of the vibration source to the human body, however, provides a potentially dangerous combination. The U.S. space program, worried about the harmful effects of rocket flight on astronauts, ordered vibration tests that used cockpit seats mounted on vibration tables to transfer "brown note" and other frequencies directly to the human subjects. Very high power levels of 160 dB were achieved at frequencies of 2–3 Hz. Test frequencies ranged from 0.5 Hz to 40 Hz. Test subjects suffered motor ataxia, nausea, visual disturbance, degraded task performance and difficulties in communication. These tests are assumed by researchers to be the nucleus of the current urban myth.
The report "A Review of Published Research on Low Frequency Noise and its Effects" contains a long list of research about exposure to high-level infrasound among humans and animals. For instance, in 1972, Borredon exposed 42 young men to tones at 7.5 Hz at 130 dB for 50 minutes. This exposure caused no adverse effects other than reported drowsiness and a slight blood pressure increase. In 1975, Slarve and Johnson exposed four male subjects to infrasound at frequencies from 1 to 20 Hz, for eight minutes at a time, at levels up to 144 dB SPL. There was no evidence of any detrimental effect other than middle ear discomfort. Tests of high-intensity infrasound on animals resulted in measurable changes, such as cell changes and ruptured blood vessel walls.
In February 2005 the television show MythBusters used twelve Meyer Sound 700-HP subwoofers—a model and quantity that has been employed for major rock concerts. Normal operating frequency range of the selected subwoofer model was 28 Hz to 150 Hz but the 12 enclosures at MythBusters had been specially modified for deeper bass extension. Roger Schwenke and John Meyer directed the Meyer Sound team in devising a special test rig that would produce very high sound levels at infrasonic frequencies. The subwoofers' tuning portswere blocked and their input cards were altered. The modified cabinets were positioned in an open ring configuration: four stacks of three subwoofers each. Test signals were generated by a SIM 3 audio analyzer, with its software modified to produce infrasonic tones. A Brüel & Kjær sound level analyzer, fed with an attenuated signal from a model 4189 measurement microphone, displayed and recorded sound pressure levels. The experimenters on the show tried a series of frequencies as low as 5 Hz, attaining a level of 120 decibels of sound pressure at 9 Hz and up to 153 dB at frequencies above 20 Hz, but the rumored physiological effects did not materialize. The test subjects all reported some physical anxiety and shortness of breath, even a small amount of nausea, but this was dismissed by the experimenters, noting that sound at that frequency and intensity moves air rapidly in and out of one's lungs. The show declared the brown note myth "busted."
In the comic book series Transmetropolitan, the main character, Spider Jerusalem, wields a "Bowel Disruptor" that operates using ultrasonic waves, with varying settings of intensity.
In the season 3 episode "World Wide Recorder Concert" (episode 17) of the animated show South Park in 2000, the brown note myth is featured prominently; the boys rewrite the music for a worldwide recorder concert to include the brown note, with the result that everyone in the world defecates.
In the season 4 episode "The Curse of Shiva" (episode 13) of The League, Taco (Jon Lajoie) has found a use for the thousands of discarded vuvuzela instruments left over from the 2010 FIFA World Cup hosted by South Africa. The instruments were tinkered with to produce the brown note with hopes that it could then be sold to the military as a weapon.
In the season 1 episode "Angel Boy" (episode 4) of the Adult Swim show Tim and Eric's Bedtime Stories, the character Scotty sings a note that causes attendees at a birthday party to have intense gastrointestinal distress and defecate uncontrollably.
In the season 6 episode "Edie's Wedding" (episode 4) of Archer, Doctor Krieger builds an ultrasonic weapon which hypothetically produces the brown note